5KJL
SMYD2 in complex with AZ378
Summary for 5KJL
Entry DOI | 10.2210/pdb5kjl/pdb |
Related | 5KJK 5KJM 5KJN |
Descriptor | N-lysine methyltransferase SMYD2, S-ADENOSYLMETHIONINE, ZINC ION, ... (4 entities in total) |
Functional Keywords | tranferase, histone methyltransferase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm, cytosol : Q9NRG4 |
Total number of polymer chains | 1 |
Total formula weight | 49938.25 |
Authors | Ferguson, A. (deposition date: 2016-06-20, release date: 2016-12-07, Last modification date: 2023-09-27) |
Primary citation | Cowen, S.D.,Russell, D.,Dakin, L.A.,Chen, H.,Larsen, N.A.,Godin, R.,Throner, S.,Zheng, X.,Molina, A.,Wu, J.,Cheung, T.,Howard, T.,Garcia-Arenas, R.,Keen, N.,Pendleton, C.S.,Pietenpol, J.A.,Ferguson, A.D. Design, Synthesis, and Biological Activity of Substrate Competitive SMYD2 Inhibitors. J. Med. Chem., 59:11079-11097, 2016 Cited by PubMed: 28002961PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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