5KJM

SMYD2 in complex with AZ931

Summary for 5KJM

Entry DOI	10.2210/pdb5kjm/pdb
Related	5KJK 5KJL 5KJN
Descriptor	N-lysine methyltransferase SMYD2, S-ADENOSYLMETHIONINE, 6-[2-[4-[2-(3,4-dichlorophenyl)ethyl]piperazin-1-yl]phenyl]-~{N}-(3-pyrrolidin-1-ylpropyl)-2~{H}-pyrazolo[3,4-b]pyridine-4-carboxamide, ... (5 entities in total)
Functional Keywords	tranferase, histone methyltransferase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm, cytosol : Q9NRG4
Total number of polymer chains	1
Total formula weight	50544.83
Authors	Ferguson, A. (deposition date: 2016-06-20, release date: 2016-12-07, Last modification date: 2023-09-27)
Primary citation	Cowen, S.D.,Russell, D.,Dakin, L.A.,Chen, H.,Larsen, N.A.,Godin, R.,Throner, S.,Zheng, X.,Molina, A.,Wu, J.,Cheung, T.,Howard, T.,Garcia-Arenas, R.,Keen, N.,Pendleton, C.S.,Pietenpol, J.A.,Ferguson, A.D. Design, Synthesis, and Biological Activity of Substrate Competitive SMYD2 Inhibitors. J. Med. Chem., 59:11079-11097, 2016 Cited by PubMed: 28002961 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.19 Å)

Structure validation