5JHN
Structure of G9a SET-domain with Histone H3K9Ala mutant peptide and bound S-adenosylmethionine
Summary for 5JHN
Entry DOI | 10.2210/pdb5jhn/pdb |
Related | 5JIN 5JIY 5JJ0 |
Descriptor | Histone-lysine N-methyltransferase EHMT2, Histone H3.1 peptide with K9A mutation, ZINC ION, ... (5 entities in total) |
Functional Keywords | set-domain, histone methyl transferase, histone peptide, transferase |
Biological source | Homo sapiens (Human) More |
Cellular location | Nucleus : Q96KQ7 |
Total number of polymer chains | 4 |
Total formula weight | 66802.29 |
Authors | Jayaram, H.,Bellon, S.F.,Poy, F. (deposition date: 2016-04-21, release date: 2016-07-06, Last modification date: 2024-03-06) |
Primary citation | Jayaram, H.,Hoelper, D.,Jain, S.U.,Cantone, N.,Lundgren, S.M.,Poy, F.,Allis, C.D.,Cummings, R.,Bellon, S.,Lewis, P.W. S-adenosyl methionine is necessary for inhibition of the methyltransferase G9a by the lysine 9 to methionine mutation on histone H3. Proc.Natl.Acad.Sci.USA, 113:6182-6187, 2016 Cited by PubMed: 27185940DOI: 10.1073/pnas.1605523113 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.67 Å) |
Structure validation
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