5FON

Crystal structure of the Cryptosporidium muris cytosolic leucyl-tRNA synthetase editing domain (apo structure)

Summary for 5FON

• Entry DOI: 10.2210/pdb5fon/pdb
• Related: 5FO4 5FOC 5FOD 5FOF 5FOG 5FOL 5FOM
• Descriptor: LEUCYL-TRNA SYNTHETASE (3 entities in total)
• Functional Keywords: ligase, cryptosporidium, leucine-trna ligase (leurs) activity, atp + l-leucine + trna(leucine) give amp + diphosphate + l-leucyl-trna(leucine), post-transfer editing activity of leurs, aminoacyl-trna synthetase, protein biosynthesis, novel boron inhibitors of the editing site of leurs
• Biological source: CRYPTOSPORIDIUM MURIS; More
• Total number of polymer chains: 4
• Total formula weight: 131678.93

Authors

Palencia, A.,Liu, R.J.,Lukarska, M.,Gut, J.,Bougdour, A.,Touquet, B.,Wang, E.D.,Alley, M.R.K.,Rosenthal, P.J.,Hakimi, M.A.,Cusack, S. (deposition date: 2015-11-24, release date: 2016-08-03, Last modification date: 2024-01-10)

• Primary citation: Palencia, A.,Liu, R.,Lukarska, M.,Gut, J.,Bougdour, A.,Touquet, B.,Wang, E.,Li, X.,Alley, M.R.K.,Freund, Y.R.,Rosenthal, P.J.,Hakimi, M.,Cusack, S.; Cryptosporidium and Toxoplasma Parasites are Inhibited by a Benzoxaborole Targeting Leucyl-tRNA Synthetase.; Antimicrob.Agents Chemother., 60:5817-, 2016; PubMed: 27431220; DOI: 10.1128/AAC.00873-16

Experimental method

X-RAY DIFFRACTION (2.7 Å)