5F5G
Structure of E.Coli GlpG Y205F mutant complexed with peptidic inhibitor Ac-RMA-CHO in the DMPC/CHAPSO bicelle
Summary for 5F5G
Entry DOI | 10.2210/pdb5f5g/pdb |
Related | 5F5B 5F5D 5F5J 5F5K |
Descriptor | Rhomboid protease GlpG, ACE-ARG-MET-ALA-aldehyde (3 entities in total) |
Functional Keywords | glpg, rhomboid, intramembrane protease, bicelle, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Escherichia coli More |
Cellular location | Cell inner membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein : A0A0J2E248 |
Total number of polymer chains | 2 |
Total formula weight | 24187.65 |
Authors | Urban, S.,Cho, S.,Dickey, S.W. (deposition date: 2015-12-04, release date: 2016-04-06, Last modification date: 2024-07-10) |
Primary citation | Cho, S.,Dickey, S.W.,Urban, S. Crystal Structures and Inhibition Kinetics Reveal a Two-Stage Catalytic Mechanism with Drug Design Implications for Rhomboid Proteolysis. Mol.Cell, 61:329-340, 2016 Cited by PubMed: 26805573DOI: 10.1016/j.molcel.2015.12.022 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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