5F5D

Crystal structures and Inhibition kinetics reveal a two-state catalytic mechanism with drug design implications for rhomboid proteolysis

Summary for 5F5D

Entry DOI	10.2210/pdb5f5d/pdb
Related	5F5B 5F5G 5F5J 5F5K
Descriptor	Rhomboid protease GlpG (2 entities in total)
Functional Keywords	intramembrane protease, rhomboid, bicelle, hydrolase
Biological source	Escherichia coli
Cellular location	Cell inner membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein : A0A0J2E248
Total number of polymer chains	1
Total formula weight	23800.13
Authors	Urban, S.,Cho, S.,Dickey, S.W. (deposition date: 2015-12-04, release date: 2016-02-24, Last modification date: 2023-09-27)
Primary citation	Cho, S.,Dickey, S.W.,Urban, S. Crystal Structures and Inhibition Kinetics Reveal a Two-Stage Catalytic Mechanism with Drug Design Implications for Rhomboid Proteolysis. Mol.Cell, 61:329-340, 2016 Cited by PubMed: 26805573 DOI: 10.1016/j.molcel.2015.12.022 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation