5ETK
E. coli 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase complexed with AMPCPP and inhibitor at 1.09 angstrom resolution
Summary for 5ETK
Entry DOI | 10.2210/pdb5etk/pdb |
Related | 5ETL 5ETM 5ETN 5ETO 5ETP 5ETQ 5ETR 5ETS 5ETT 5ETV |
Descriptor | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, 2-azanyl-8-[(2-fluorophenyl)methylsulfanyl]-1,9-dihydropurin-6-one, ... (7 entities in total) |
Functional Keywords | inhibitor, complex, ampcpp, pyrophosphokinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Escherichia coli |
Total number of polymer chains | 1 |
Total formula weight | 19363.66 |
Authors | Dennis, M.L.,Peat, T.S.,Swarbrick, J.D. (deposition date: 2015-11-17, release date: 2016-05-04, Last modification date: 2023-09-27) |
Primary citation | Dennis, M.L.,Pitcher, N.P.,Lee, M.D.,DeBono, A.J.,Wang, Z.C.,Harjani, J.R.,Rahmani, R.,Cleary, B.,Peat, T.S.,Baell, J.B.,Swarbrick, J.D. Structural Basis for the Selective Binding of Inhibitors to 6-Hydroxymethyl-7,8-dihydropterin Pyrophosphokinase from Staphylococcus aureus and Escherichia coli. J.Med.Chem., 59:5248-5263, 2016 Cited by PubMed: 27094768DOI: 10.1021/acs.jmedchem.6b00002 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.09 Å) |
Structure validation
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