5ETO

E. coli 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase complexed with AMPCPP and inhibitor at 1.07 angstrom resolution

Summary for 5ETO

Entry DOI	10.2210/pdb5eto/pdb
Related	5ETK 5ETL 5ETM 5ETN 5ETP 5ETQ 5ETR 5ETS 5ETT 5ETV
Descriptor	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, 4-[(2-azanyl-6-oxidanylidene-1,9-dihydropurin-8-yl)sulfanylmethyl]-3-fluoranyl-benzenecarbonitrile, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, ... (6 entities in total)
Functional Keywords	inhibitor, complex, ampcpp, pyrophosphokinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Escherichia coli
Total number of polymer chains	1
Total formula weight	19365.68
Authors	Dennis, M.L.,Peat, T.S.,Swarbrick, J.D. (deposition date: 2015-11-17, release date: 2016-05-04, Last modification date: 2023-09-27)
Primary citation	Dennis, M.L.,Pitcher, N.P.,Lee, M.D.,DeBono, A.J.,Wang, Z.C.,Harjani, J.R.,Rahmani, R.,Cleary, B.,Peat, T.S.,Baell, J.B.,Swarbrick, J.D. Structural Basis for the Selective Binding of Inhibitors to 6-Hydroxymethyl-7,8-dihydropterin Pyrophosphokinase from Staphylococcus aureus and Escherichia coli. J.Med.Chem., 59:5248-5263, 2016 Cited by PubMed: 27094768 DOI: 10.1021/acs.jmedchem.6b00002 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.07 Å)

Structure validation