5EA9

Crystal Structure of Trypanosoma cruzi Dihydroorotate Dehydrogenase in Complex with Neq0130

5EA9 の概要

• エントリーDOI: 10.2210/pdb5ea9/pdb
• 関連するPDBエントリー: 5E93
• 分子名称: Dihydroorotate dehydrogenase (fumarate), 5-[(E)-3-thiophen-2-ylprop-2-enylidene]-1,3-diazinane-2,4,6-trione, GLYCEROL, ... (7 entities in total)
• 機能のキーワード: t. cruzi, dihydroorotate dehydrogenase, covalent inhibitor, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Trypanosoma cruzi strain CL Brener
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 71920.04

構造登録者

Rocha, J.R.,Inaoka, D.K.,Cheleski, J.,Shiba, T.,Harada, S.,Montanari, C.A.,Kita, K. (登録日: 2015-10-15, 公開日: 2016-10-19, 最終更新日: 2020-02-19)

• 主引用文献: Rocha, J.R.,Cheleski, J.,Inaoka, D.K.,Avelar, L.A.,Ribeiro, J.F.R.,Wiggers, H.J.,Albuquerque, S.,Shiba, T.,Harada, S.,Kita, K.,Silva, A.B.F.,Montanari, C.A.; Exploring Trypanosoma cruzi Dihydroorotate Dehydrogenase Active Site Plasticity for the Discovery of Potent and Selective Inhibitors with Trypanocidal Activity; To be Published,

実験手法

X-RAY DIFFRACTION (1.71 Å)