5E90
TGF-BETA RECEPTOR TYPE 1 KINASE DOMAIN (T204D,I211V,Y249F, S280T,Y282F,S287N,A350C,L352F) IN COMPLEX WITH 3-AMINO-6- [4-(2-HYDROXYETHYL)PHENYL]-N-[4-(MORPHOLIN-4-YL)PYRIDIN-3-YL]PYRAZINE-2-CARBOXAMIDE
Summary for 5E90
Entry DOI | 10.2210/pdb5e90/pdb |
Related | 5E8S 5E8T 5E8U 5E8V 5E8W 5E8X 5E8Y 5E8Z 5E91 5E92 |
Descriptor | TGF-beta receptor type-1, 3-amino-6-[4-(2-hydroxyethyl)phenyl]-N-[4-(morpholin-4-yl)pyridin-3-yl]pyrazine-2-carboxamide (3 entities in total) |
Functional Keywords | alk5, sb431542, kinase domain, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cell membrane ; Single-pass type I membrane protein : P36897 |
Total number of polymer chains | 1 |
Total formula weight | 35647.04 |
Authors | Sheriff, S. (deposition date: 2015-10-14, release date: 2016-05-11, Last modification date: 2023-09-27) |
Primary citation | Tebben, A.J.,Ruzanov, M.,Gao, M.,Xie, D.,Kiefer, S.E.,Yan, C.,Newitt, J.A.,Zhang, L.,Kim, K.,Lu, H.,Kopcho, L.M.,Sheriff, S. Crystal structures of apo and inhibitor-bound TGF beta R2 kinase domain: insights into TGF beta R isoform selectivity. Acta Crystallogr D Struct Biol, 72:658-674, 2016 Cited by PubMed: 27139629DOI: 10.1107/S2059798316003624 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
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