5E8U
TGF-BETA RECEPTOR TYPE 1 KINASE DOMAIN (T204D,I211V,Y249F,S280T, Y282F,S287N,A350C,L352F)
Summary for 5E8U
| Entry DOI | 10.2210/pdb5e8u/pdb |
| Related | 5E8S 5E8T 5E8V 5E8W 5E8X 5E8Y 5E8Z 5E90 5E91 5E92 |
| Descriptor | TGF-beta receptor type-1, GLYCEROL (3 entities in total) |
| Functional Keywords | alk5, kinase domain, transferase |
| Biological source | Homo sapiens (Human) |
| Cellular location | Cell membrane ; Single-pass type I membrane protein : P36897 |
| Total number of polymer chains | 1 |
| Total formula weight | 35502.86 |
| Authors | Sheriff, S. (deposition date: 2015-10-14, release date: 2016-05-11, Last modification date: 2023-09-27) |
| Primary citation | Tebben, A.J.,Ruzanov, M.,Gao, M.,Xie, D.,Kiefer, S.E.,Yan, C.,Newitt, J.A.,Zhang, L.,Kim, K.,Lu, H.,Kopcho, L.M.,Sheriff, S. Crystal structures of apo and inhibitor-bound TGF beta R2 kinase domain: insights into TGF beta R isoform selectivity. Acta Crystallogr D Struct Biol, 72:658-674, 2016 Cited by PubMed: 27139629DOI: 10.1107/S2059798316003624 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.03 Å) |
Structure validation
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