5DYT
Crystal structure of human butyrylcholinesterase in complex with N-((1-benzylpiperidin-3-yl)methyl)-N-methylnaphthalene-2-sulfonamide
Summary for 5DYT
Entry DOI | 10.2210/pdb5dyt/pdb |
Descriptor | Cholinesterase, beta-L-fucopyranose, DI(HYDROXYETHYL)ETHER, ... (12 entities in total) |
Functional Keywords | human butyrylcholinesterase, ad, alzheimer disease, sulfonamide, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 126466.99 |
Authors | Coquelle, N.,Brus, B.,Colletier, J.P. (deposition date: 2015-09-25, release date: 2016-10-05, Last modification date: 2024-05-01) |
Primary citation | Kosak, U.,Brus, B.,Knez, D.,Sink, R.,Zakelj, S.,Trontelj, J.,Pislar, A.,Slenc, J.,Gobec, M.,Zivin, M.,Tratnjek, L.,Perse, M.,Saat, K.,Podkowa, A.,Filipek, B.,Nachon, F.,Brazzolotto, X.,Wieckowska, A.,Malawska, B.,Stojan, J.,Rascan, I.M.,Kos, J.,Coquelle, N.,Colletier, J.P.,Gobec, S. Development of an in-vivo active reversible butyrylcholinesterase inhibitor. Sci Rep, 6:39495-39495, 2016 Cited by PubMed: 28000737DOI: 10.1038/srep39495 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.55 Å) |
Structure validation
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