5BVP
The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta
Summary for 5BVP
Entry DOI | 10.2210/pdb5bvp/pdb |
Descriptor | canakinumab Fab heavy-chain, Interleukin-1 beta, Canakinumab Fab light-chain, ... (5 entities in total) |
Functional Keywords | immunoglobulin, fab, cytokine, beta trefoil, immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 65027.70 |
Authors | Rondeau, J.M. (deposition date: 2015-06-05, release date: 2015-09-02, Last modification date: 2024-01-10) |
Primary citation | Rondeau, J.M.,Ramage, P.,Zurini, M.,Gram, H. The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1 beta. Mabs, 7:1151-1160, 2015 Cited by PubMed: 26284424DOI: 10.1080/19420862.2015.1081323 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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