Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

5BVP

The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta

Functional Information from GO Data
ChainGOidnamespacecontents
I0005125molecular_functioncytokine activity
I0005615cellular_componentextracellular space
I0006954biological_processinflammatory response
I0006955biological_processimmune response
Functional Information from PDB Data
site_idAC1
Number of Residues2
Detailsbinding site for residue CL I 201
ChainResidue
IARG11
IMET36

site_idAC2
Number of Residues3
Detailsbinding site for residue CL L 301
ChainResidue
IARG98
LPRO59
LARG61

Functional Information from PROSITE/UniProt
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH
ChainResidueDetails
LTYR192-HIS198
HTYR199-HIS205

site_idPS00253
Number of Residues21
DetailsINTERLEUKIN_1 Interleukin-1 signature. FeSAqfPnwYISTsqaenmpV
ChainResidueDetails
IPHE112-VAL132

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsSITE: Involved in receptor binding
ChainResidueDetails
IARG4

site_idSWS_FT_FI2
Number of Residues5
DetailsSITE: Important for interaction with integrin => ECO:0000269|PubMed:29030430
ChainResidueDetails
ILYS55
ILYS63
ILYS65
ILYS74
ILYS88

219869

PDB entries from 2024-05-15

PDB statisticsPDBj update infoContact PDBjnumon