5BO3

Bianthranilate-like inhibitor with 5 atom "line" and phosphonate "hook" fishing for hydrogen bond donors in Mycobacterium tuberculosis anthranilate phosphoribosyltransferase (AnPRT; trpD)

Summary for 5BO3

• Entry DOI: 10.2210/pdb5bo3/pdb
• Related: 3QR9 4IJ1 5BO2
• Descriptor: Anthranilate phosphoribosyltransferase, 2-[(2-carboxyphenyl)amino]-5-(4-phosphonobutoxy)benzoic acid, IMIDAZOLE, ... (4 entities in total)
• Functional Keywords: inhibitor, complex, lobenzarit-like analogue, tb structural genomics consortium, tbsgc, magnesium binding, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Mycobacterium tuberculosis
• Total number of polymer chains: 2
• Total formula weight: 78852.85

Authors

Evans, G.L.,Baker, E.N.,Lott, J.S.,TB Structural Genomics Consortium (TBSGC) (deposition date: 2015-05-27, release date: 2016-06-01, Last modification date: 2023-09-27)

• Primary citation: Evans, G.L.,Baker, E.N.,Lott, J.S.; Binding and mimicking of the phosphate-rich substrate, PRPP.; To be Published,

Experimental method

X-RAY DIFFRACTION (1.75 Å)