5BO2

Bianthranilate-like inhibitor with 4-atom "line" and phosphonate "hook" fishing for hydrogen bond donors in Mycobacterium tuberculosis anthranilate phosphoribosyltransferase (AnPRT; trpD)

Summary for 5BO2

• Entry DOI: 10.2210/pdb5bo2/pdb
• Related: 3QR9 4IJ1 5BO3
• Descriptor: Anthranilate phosphoribosyltransferase, 2-[(2-carboxyphenyl)amino]-5-(3-phosphonopropoxy)benzoic acid, IMIDAZOLE, ... (4 entities in total)
• Functional Keywords: lobenzarit-like analogue, tb structural genomics consortium, tbsgc, magnesium binding, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Mycobacterium tuberculosis
• Total number of polymer chains: 2
• Total formula weight: 79032.05

Authors

Evans, G.L.,Baker, E.N.,Lott, J.S.,TB Structural Genomics Consortium (TBSGC) (deposition date: 2015-05-27, release date: 2016-06-01, Last modification date: 2023-09-27)

• Primary citation: Evans, G.L.,Baker, E.N.,Lott, J.S.; Binding and mimicking of the phosphate-rich substrate, PRPP.; To be Published,

Experimental method

X-RAY DIFFRACTION (2 Å)