5AXQ

Crystal structure of the catalytic domain of PDE10A complexed with highly potent and brain-penetrant PDE10A Inhibitor with 2-oxindole scaffold

Summary for 5AXQ

• Entry DOI: 10.2210/pdb5axq/pdb
• Related: 5AXP
• Descriptor: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, MAGNESIUM ION, ZINC ION, ... (6 entities in total)
• Functional Keywords: hydrolase/hydrolase inhibitor, hydrolase-hydrolase inhibitor complex
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm: Q9Y233
• Total number of polymer chains: 2
• Total formula weight: 78905.55

Authors

Oki, H.,Zama, Y. (deposition date: 2015-07-31, release date: 2015-11-11, Last modification date: 2024-03-20)

• Primary citation: Yoshikawa, M.,Kamisaki, H.,Kunitomo, J.,Oki, H.,Kokubo, H.,Suzuki, A.,Ikemoto, T.,Nakashima, K.,Kamiguchi, N.,Harada, A.,Kimura, H.,Taniguchi, T.; Design and synthesis of a novel 2-oxindole scaffold as a highly potent and brain-penetrant phosphodiesterase 10A inhibitor; Bioorg.Med.Chem., 23:7138-7149, 2015; PubMed: 26494583; DOI: 10.1016/j.bmc.2015.10.002

Experimental method

X-RAY DIFFRACTION (1.77 Å)