5AWN
Crystal structure of Human anti-HIV-1 broadly neutralizing antibody 3BC176 Fab
Summary for 5AWN
Entry DOI | 10.2210/pdb5awn/pdb |
Related | 5CCK |
Descriptor | Heavy chain of 3BC176 Fab, Light chain of 3BC176 Fab (3 entities in total) |
Functional Keywords | hiv-1, env, broadly neutralizing antibody, immune system |
Biological source | Homo sapiens More |
Total number of polymer chains | 2 |
Total formula weight | 48132.87 |
Authors | Lee, J.H.,Wilson, I.A.,Ward, A.B. (deposition date: 2015-07-06, release date: 2015-11-11, Last modification date: 2023-11-08) |
Primary citation | Lee, J.H.,Leaman, D.P.,Kim, A.S.,Torrents de la Pena, A.,Sliepen, K.,Yasmeen, A.,Derking, R.,Ramos, A.,de Taeye, S.W.,Ozorowski, G.,Klein, F.,Burton, D.R.,Nussenzweig, M.C.,Poignard, P.,Moore, J.P.,Klasse, P.J.,Sanders, R.W.,Zwick, M.B.,Wilson, I.A.,Ward, A.B. Antibodies to a conformational epitope on gp41 neutralize HIV-1 by destabilizing the Env spike. Nat Commun, 6:8167-8167, 2015 Cited by PubMed: 26404402DOI: 10.1038/ncomms9167 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.887 Å) |
Structure validation
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