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5CCK

Crystal structure of Human anti-HIV-1 broadly neutralizing antibody 3BC315 Fab

Summary for 5CCK
Entry DOI10.2210/pdb5cck/pdb
Related5AWN
EMDB information3067
DescriptorAntibody 3BC315 Fab heavy chain, Antibody 3BC315 Fab light chain, 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, ... (4 entities in total)
Functional Keywordshiv-1, env, bnab, antibody, immune system
Biological sourceHomo sapiens
More
Total number of polymer chains2
Total formula weight48230.16
Authors
Lee, J.H.,Ward, A.B.,Wilson, I.A. (deposition date: 2015-07-02, release date: 2015-10-07, Last modification date: 2019-12-11)
Primary citationLee, J.H.,Leaman, D.P.,Kim, A.S.,Torrents de la Pena, A.,Sliepen, K.,Yasmeen, A.,Derking, R.,Ramos, A.,de Taeye, S.W.,Ozorowski, G.,Klein, F.,Burton, D.R.,Nussenzweig, M.C.,Poignard, P.,Moore, J.P.,Klasse, P.J.,Sanders, R.W.,Zwick, M.B.,Wilson, I.A.,Ward, A.B.
Antibodies to a conformational epitope on gp41 neutralize HIV-1 by destabilizing the Env spike.
Nat Commun, 6:8167-8167, 2015
Cited by
PubMed: 26404402
DOI: 10.1038/ncomms9167
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.95 Å)
Structure validation

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