4Z7G

Crystal structure of human IRE1 cytoplasmic kinase-RNase region - apo

Summary for 4Z7G

Entry DOI	10.2210/pdb4z7g/pdb
Descriptor	Serine/threonine-protein kinase/endoribonuclease IRE1, SODIUM ION (3 entities in total)
Functional Keywords	transferase, kinase, rnase, unfolded protein response
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	95557.62
Authors	Bayliss, R.,Joshi, A. (deposition date: 2015-04-07, release date: 2015-05-27, Last modification date: 2024-01-10)
Primary citation	Joshi, A.,Newbatt, Y.,McAndrew, P.C.,Stubbs, M.,Burke, R.,Richards, M.W.,Bhatia, C.,Caldwell, J.J.,McHardy, T.,Collins, I.,Bayliss, R. Molecular mechanisms of human IRE1 activation through dimerization and ligand binding. Oncotarget, 6:13019-13035, 2015 Cited by PubMed: 25968568 DOI: 10.18632/oncotarget.3864 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation