4Y2R
Structure of soluble epoxide hydrolase in complex with 2-(piperazin-1-yl)nicotinonitrile
Summary for 4Y2R
| Entry DOI | 10.2210/pdb4y2r/pdb |
| Related | 4Y2J 4Y2P 4Y2Q 4Y2S 4Y2T 4Y2U 4Y2V 4Y2X 4Y2Y |
| Descriptor | Bifunctional epoxide hydrolase 2, MAGNESIUM ION, 2-(piperazin-1-yl)pyridine-3-carbonitrile, ... (4 entities in total) |
| Functional Keywords | hydrolase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 63727.05 |
| Authors | Amano, Y.,Yamaguchi, T. (deposition date: 2015-02-10, release date: 2015-05-06, Last modification date: 2023-11-08) |
| Primary citation | Amano, Y.,Tanabe, E.,Yamaguchi, T. Identification of N-ethylmethylamine as a novel scaffold for inhibitors of soluble epoxide hydrolase by crystallographic fragment screening Bioorg.Med.Chem., 23:2310-2317, 2015 Cited by PubMed: 25862210DOI: 10.1016/j.bmc.2015.03.083 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.45 Å) |
Structure validation
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