4XIQ
Discovery of novel oxazepine and diazepine carboxamides as two new classes of heat shock protein 90 inhibitors
Summary for 4XIQ
Entry DOI | 10.2210/pdb4xiq/pdb |
Related | 4XIP 4XIR 4XIT |
Descriptor | Heat shock protein HSP 90-alpha, 8,11,11-trimethyl-9-oxo-6,7,9,10,11,12-hexahydroindolo[2,1-d][1,5]benzoxazepine-3-carboxamide, GLYCEROL, ... (4 entities in total) |
Functional Keywords | chaperone-chaperone inhibitor complex, chaperone/chaperone inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: P07900 |
Total number of polymer chains | 1 |
Total formula weight | 26705.99 |
Authors | Neubert, T.,Zuccola, H.J. (deposition date: 2015-01-07, release date: 2015-03-04, Last modification date: 2024-02-28) |
Primary citation | Neubert, T.,Numa, M.,Ernst, J.,Clemens, J.,Krenitsky, P.,Liu, M.,Fleck, B.,Woody, L.,Zuccola, H.,Stamos, D. Discovery of novel oxazepine and diazepine carboxamides as two new classes of heat shock protein 90 inhibitors. Bioorg.Med.Chem.Lett., 25:1338-1342, 2015 Cited by PubMed: 25677667DOI: 10.1016/j.bmcl.2015.01.023 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.84 Å) |
Structure validation
Download full validation report