4XIP

Discovery of novel oxazepine and diazepine carboxamides as two new classes of heat shock protein 90 inhibitors

Summary for 4XIP

• Entry DOI: 10.2210/pdb4xip/pdb
• Related: 4XIQ 4XIR 4XIT
• Descriptor: Heat shock protein HSP 90-alpha, 4-(3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-1-yl)benzamide (3 entities in total)
• Functional Keywords: chaperone-chaperone inhibitor complex, chaperone/chaperone inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm: P07900
• Total number of polymer chains: 1
• Total formula weight: 26479.76

Authors

Zuccola, H.J.,Neubert, T. (deposition date: 2015-01-07, release date: 2015-03-04, Last modification date: 2024-02-28)

• Primary citation: Neubert, T.,Numa, M.,Ernst, J.,Clemens, J.,Krenitsky, P.,Liu, M.,Fleck, B.,Woody, L.,Zuccola, H.,Stamos, D.; Discovery of novel oxazepine and diazepine carboxamides as two new classes of heat shock protein 90 inhibitors.; Bioorg.Med.Chem.Lett., 25:1338-1342, 2015; PubMed: 25677667; DOI: 10.1016/j.bmcl.2015.01.023

Experimental method

X-RAY DIFFRACTION (1.7 Å)