4X3R

Avi-GCPII structure in complex with FITC-conjugated GCPII-specific inhibitor

Summary for 4X3R

Entry DOI	10.2210/pdb4x3r/pdb
Descriptor	Glutamate carboxypeptidase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
Functional Keywords	glycoprotein, metallopeptidase, inhibitor, hydrolase
Biological source	Homo sapiens (Human)
Cellular location	Cell membrane ; Single-pass type II membrane protein . Isoform PSMA': Cytoplasm: Q04609
Total number of polymer chains	1
Total formula weight	87653.81
Authors	Tykvart, J.,Konvalinka, J. (deposition date: 2014-12-01, release date: 2015-10-14, Last modification date: 2024-01-10)
Primary citation	Tykvart, J.,Schimer, J.,Jancarik, A.,Barinkova, J.,Navratil, V.,Starkova, J.,Sramkova, K.,Konvalinka, J.,Majer, P.,Sacha, P. Design of highly potent urea-based, exosite-binding inhibitors selective for glutamate carboxypeptidase II. J.Med.Chem., 58:4357-4363, 2015 Cited by PubMed: 25923815 DOI: 10.1021/acs.jmedchem.5b00278 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.86 Å)

Structure validation