4X3R
Avi-GCPII structure in complex with FITC-conjugated GCPII-specific inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Glutamate carboxypeptidase 2 | polymer | 739 | 83200.6 | 1 | UniProt (Q04609) Pfam (PF02225) Pfam (PF04389) Pfam (PF04253) In PDB | Homo sapiens (Human) | Cell growth-inhibiting gene 27 protein,Folate hydrolase 1,Folylpoly-gamma-glutamate carboxypeptidase,FGCP,Glutamate carboxypeptidase II,GCPII,Membrane glutamate carboxypeptidase,mGCP,N-acetylated-alpha-linked acidic dipeptidase I,NAALADase I,Prostate-specific membrane antigen,PSMA,Pteroylpoly-gamma-glutamate carboxypeptidase |
| 2 | B, C, D | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 3 | In PDB GlyTouCan (G42666HT) | |||
| 3 | E | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 4 | F | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G81315DD) | |||
| 5 | A | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 6 | A | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 7 | A | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 8 | A | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 9 | A | N-({(1S)-5-[(4-bromobenzyl)({6-[4-(4-{4-[4-carboxy-3-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoyl]piperazin-1-yl}phenyl)piperazin-1-yl]pyridin-3-yl}carbonyl)amino]-1-carboxypentyl}carbamoyl)-L-glutamic acid | non-polymer | 1196.1 | 1 | Chemie (686) | |||
| 10 | water | water | 18.0 | 632 | Chemie (HOH) |
Sequence modifications
A: 44 - 750 (UniProt: Q04609)
| PDB | External Database | Details |
|---|---|---|
| Arg 12 | - | expression tag |
| Ser 13 | - | expression tag |
| Gly 14 | - | expression tag |
| Leu 15 | - | expression tag |
| Asn 16 | - | expression tag |
| Asp 17 | - | expression tag |
| Ile 18 | - | expression tag |
| Phe 19 | - | expression tag |
| Glu 20 | - | expression tag |
| Ala 21 | - | expression tag |
| Gln 22 | - | expression tag |
| Lys 23 | - | expression tag |
| Ile 24 | - | expression tag |
| Glu 25 | - | expression tag |
| Trp 26 | - | expression tag |
| His 27 | - | expression tag |
| Glu 28 | - | expression tag |
| Gly 29 | - | expression tag |
| Ser 30 | - | expression tag |
| Gly 31 | - | expression tag |
| Ser 32 | - | expression tag |
| Gly 33 | - | expression tag |
| Ser 34 | - | expression tag |
| Glu 35 | - | expression tag |
| Asn 36 | - | expression tag |
| Leu 37 | - | expression tag |
| Tyr 38 | - | expression tag |
| Phe 39 | - | expression tag |
| Gln 40 | - | expression tag |
| Gly 41 | - | expression tag |
| Arg 42 | - | expression tag |
| Ser 43 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 83200.6 | |
| Branched | Number of molecules | 5 |
| Total formula weight | 2608.4 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1844.8 | |
| All* | Total formula weight | 87653.8 |
