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4WYC

Crystal structure of 7,8-diaminopelargonic acid synthase (BioA) from Mycobacterium tuberculosis, complexed with a thiazole benzamide inhibitor

Summary for 4WYC
Entry DOI10.2210/pdb4wyc/pdb
Related4WYA 4WYD 4WYE 4WYF 4WYG
DescriptorAdenosylmethionine-8-amino-7-oxononanoate aminotransferase, PYRIDOXAL-5'-PHOSPHATE, 4-(1H-imidazol-1-yl)benzamide, ... (8 entities in total)
Functional Keywordsinhibitor complex transaminase plp, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceMycobacterium tuberculosis
Cellular locationCytoplasm : P9WQ81
Total number of polymer chains2
Total formula weight98216.25
Authors
Finzel, B.C.,Dai, R.,Geders, T.W. (deposition date: 2014-11-17, release date: 2015-07-08, Last modification date: 2023-09-27)
Primary citationDai, R.,Geders, T.W.,Liu, F.,Park, S.W.,Schnappinger, D.,Aldrich, C.C.,Finzel, B.C.
Fragment-Based Exploration of Binding Site Flexibility in Mycobacterium tuberculosis BioA.
J.Med.Chem., 58:5208-5217, 2015
Cited by
PubMed: 26068403
DOI: 10.1021/acs.jmedchem.5b00092
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.7 Å)
Structure validation

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