4WO5

Crystal structure of a BRAF kinase domain monomer

Summary for 4WO5

Entry DOI	10.2210/pdb4wo5/pdb
Related	3C4C
Descriptor	Serine/threonine-protein kinase B-raf, N-{3-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl}propane-1-sulfonamide (3 entities in total)
Functional Keywords	kinase, monomer, inhibitor, complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Nucleus : P15056
Total number of polymer chains	2
Total formula weight	69061.48
Authors	Critton, D.A. (deposition date: 2014-10-15, release date: 2014-12-03, Last modification date: 2023-09-27)
Primary citation	Thevakumaran, N.,Lavoie, H.,Critton, D.A.,Tebben, A.,Marinier, A.,Sicheri, F.,Therrien, M. Crystal structure of a BRAF kinase domain monomer explains basis for allosteric regulation. Nat.Struct.Mol.Biol., 22:37-43, 2015 Cited by PubMed: 25437913 DOI: 10.1038/nsmb.2924 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.83 Å)

Structure validation