3C4C
B-Raf Kinase in Complex with PLX4720
Summary for 3C4C
Entry DOI | 10.2210/pdb3c4c/pdb |
Related | 3C4D |
Descriptor | B-Raf proto-oncogene serine/threonine-protein kinase, N-{3-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl}propane-1-sulfonamide (3 entities in total) |
Functional Keywords | b-raf, braf, raf, proto-oncogene, serine/threonine kinase, atp-binding, cardiomyopathy, cytoplasm, disease mutation, metal-binding, nucleotide-binding, phorbol-ester binding, phosphoprotein, polymorphism, serine/threonine-protein kinase, transferase, zinc, zinc-finger |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus (By similarity): P15056 |
Total number of polymer chains | 2 |
Total formula weight | 64578.71 |
Authors | Zhang, K.Y.J.,Wang, W. (deposition date: 2008-01-29, release date: 2008-02-26, Last modification date: 2024-02-21) |
Primary citation | Tsai, J.,Lee, J.T.,Wang, W.,Zhang, J.,Cho, H.,Mamo, S.,Bremer, R.,Gillette, S.,Kong, J.,Haass, N.K.,Sproesser, K.,Li, L.,Smalley, K.S.,Fong, D.,Zhu, Y.L.,Marimuthu, A.,Nguyen, H.,Lam, B.,Liu, J.,Cheung, I.,Rice, J.,Suzuki, Y.,Luu, C.,Settachatgul, C.,Shellooe, R.,Cantwell, J.,Kim, S.H.,Schlessinger, J.,Zhang, K.Y.,West, B.L.,Powell, B.,Habets, G.,Zhang, C.,Ibrahim, P.N.,Hirth, P.,Artis, D.R.,Herlyn, M.,Bollag, G. Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity Proc.Natl.Acad.Sci.Usa, 105:3041-3046, 2008 Cited by PubMed: 18287029DOI: 10.1073/pnas.0711741105 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.57 Å) |
Structure validation
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