4WI3

Structural mapping of the human IgG1 binding site for FcRn: hu3S193 Fc mutation I253A

4WI3 の概要

• エントリーDOI: 10.2210/pdb4wi3/pdb
• 関連するPDBエントリー: 4WI2 4WI5 4WI6 4WI7 4WI8 4WI9
• 分子名称: Ig gamma-1 chain C region, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
• 機能のキーワード: human igg1, fcrn binding site, therapeutic antibody, immune system
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 50111.89

構造登録者

Farrugia, W.,Burvenich, I.J.G.,Scott, A.M.,Ramsland, P.A. (登録日: 2014-09-25, 公開日: 2015-09-30, 最終更新日: 2023-12-27)

• 主引用文献: Burvenich, I.J.G.,Farrugia, W.,Lee, F.T.,Catimel, B.,Liu, Z.,Makris, D.,Cao, D.,O'Keefe, G.,Brechbiel, M.W.,King, D.,Spirkoska, V.,Allan, L.,Ramsland, P.A.,Scott, A.M.; Structural and functional mapping of human IgG1 binding site for FcRn in vivo using human FcRn transgenic mice; To Be Published,

実験手法

X-RAY DIFFRACTION (2.703 Å)