4W9S

2-(4-(1H-tetrazol-5-yl)phenyl)-5-hydroxypyrimidin-4(3H)-one bound to influenza 2009 H1N1 endonuclease

Summary for 4W9S

Entry DOI	10.2210/pdb4w9s/pdb
Related	4LN7 4M4Q 4M5O 4M5Q 4M5R 4M5U 4MK1 4MK2 4MK5
Descriptor	Polymerase acidic protein, MANGANESE (II) ION, SULFATE ION, ... (5 entities in total)
Functional Keywords	cap-snatching, rna binding protein, rna binding protein-inhibitor complex, transcription-transcription inhibitor complex, transcription/transcription inhibitor
Biological source	Influenza A virus
Cellular location	Host cytoplasm: P13166
Total number of polymer chains	1
Total formula weight	29063.49
Authors	Bauman, J.D.,Patel, D.,Das, K.,Arnold, E. (deposition date: 2014-08-27, release date: 2014-10-01, Last modification date: 2023-09-27)
Primary citation	Sagong, H.Y.,Bauman, J.D.,Patel, D.,Das, K.,Arnold, E.,LaVoie, E.J. Phenyl Substituted 4-Hydroxypyridazin-3(2H)-ones and 5-Hydroxypyrimidin-4(3H)-ones: Inhibitors of Influenza A Endonuclease. J.Med.Chem., 57:8086-8098, 2014 Cited by PubMed: 25225968 DOI: 10.1021/jm500958x PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation