4M5O

3-HYDROXY-6-PHENYL-1,2-DIHYDROPYRIDIN-2-ONE bound to influenza 2009 H1N1 endonuclease

Summary for 4M5O

Entry DOI	10.2210/pdb4m5o/pdb
Related	4LN7 4M5Q 4M5R 4M5U 4M5V 4MK1 4MK2 4MK5
Descriptor	Polymerase PA, MANGANESE (II) ION, SULFATE ION, ... (6 entities in total)
Functional Keywords	cap-snatching, rna binding protein-inhibitor complex, rna binding protein/inhibitor
Biological source	Influenza A virus (A/Lima/WRAIR1695P/2009(H1N1))
Total number of polymer chains	1
Total formula weight	29389.80
Authors	Bauman, J.D.,Patel, D.,Das, K.,Arnold, E. (deposition date: 2013-08-08, release date: 2013-09-18, Last modification date: 2024-02-28)
Primary citation	Bauman, J.D.,Patel, D.,Baker, S.F.,Vijayan, R.S.,Xiang, A.,Parhi, A.K.,Martinez-Sobrido, L.,Lavoie, E.J.,Das, K.,Arnold, E. Crystallographic fragment screening and structure-based optimization yields a new class of influenza endonuclease inhibitors. Acs Chem.Biol., 8:2501-2508, 2013 Cited by PubMed: 23978130 DOI: 10.1021/cb400400j PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation