4U6Q
CtBP1 bound to inhibitor 2-(hydroxyimino)-3-phenylpropanoic acid
Summary for 4U6Q
Entry DOI | 10.2210/pdb4u6q/pdb |
Related | 4LCE 4U6S |
Descriptor | C-terminal-binding protein 1, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, (2E)-2-(hydroxyimino)-3-phenylpropanoic acid, ... (6 entities in total) |
Functional Keywords | rossman fold, transcription regulator, cancer, inhibitor, oxidoreductase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : Q13363 |
Total number of polymer chains | 1 |
Total formula weight | 39070.19 |
Authors | Hilbert, B.J.,Morris, B.L.,Ellis, K.C.,Paulsen, J.L.,Schiffer, C.A.,Grossman, S.R.,Royer Jr., W.E. (deposition date: 2014-07-29, release date: 2015-02-11, Last modification date: 2023-09-27) |
Primary citation | Hilbert, B.J.,Morris, B.L.,Ellis, K.C.,Paulsen, J.L.,Schiffer, C.A.,Grossman, S.R.,Royer, W.E. Structure-Guided Design of a High Affinity Inhibitor to Human CtBP. Acs Chem.Biol., 10:1118-1127, 2015 Cited by PubMed: 25636004DOI: 10.1021/cb500820b PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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