4U6P

Structural mechanism of error-free bypass of major benzo[a]pyrene adduct by human polymerase kappa

Summary for 4U6P

• Entry DOI: 10.2210/pdb4u6p/pdb
• Related: 4U7C
• Descriptor: DNA polymerase kappa, DNA (5'-D(P*GP*CP*GP*GP*AP*TP*CP*AP*C)-3'), DNA (5'-D(*TP*AP*TP*GP*GP*TP*GP*AP*TP*CP*CP*GP*C)-3'), ... (7 entities in total)
• Functional Keywords: benzo[a]pyrene-n2-guanine, dna replication, dna damage tolerance, polymerase kappa, environment pollution, transferase-dna complex, transferase/dna
• Biological source: Homo sapiens (Human); More
• Cellular location: Nucleus : Q9UBT6
• Total number of polymer chains: 6
• Total formula weight: 135014.63

Authors

Jha, V.K.,Ling, H. (deposition date: 2014-07-29, release date: 2016-01-27, Last modification date: 2023-09-27)

• Primary citation: Jha, V.,Bian, C.,Xing, G.,Ling, H.; Structure and mechanism of error-free replication past the major benzo[a]pyrene adduct by human DNA polymerase kappa.; Nucleic Acids Res., 44:4957-4967, 2016; PubMed: 27034468; DOI: 10.1093/nar/gkw204

Experimental method

X-RAY DIFFRACTION (2.593 Å)