4TYB

An Ligand-observed Mass Spectrometry-based Approach Integrated into the Fragment Based Lead Discovery Pipeline

Summary for 4TYB

• Entry DOI: 10.2210/pdb4tyb/pdb
• Related: 4TXF 4TXS 4TY8 4TY9 4TYA
• Descriptor: Polyprotein, (2R)-morpholin-4-yl(phenyl)ethanenitrile (2 entities in total)
• Functional Keywords: inhibitor, ns5b, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Hepatitis C virus
• Total number of polymer chains: 4
• Total formula weight: 251976.94

Authors

Shui, W.,Yang, C.,Lin, J.,Chen, X.,Qin, S.,Chen, S. (deposition date: 2014-07-08, release date: 2015-05-20, Last modification date: 2024-03-20)

• Primary citation: Chen, X.,Qin, S.,Chen, S.,Li, J.,Li, L.,Wang, Z.,Wang, Q.,Lin, J.,Yang, C.,Shui, W.; A ligand-observed mass spectrometry approach integrated into the fragment based lead discovery pipeline; Sci Rep, 5:8361-8361, 2015; PubMed: 25666181; DOI: 10.1038/srep08361

Experimental method

X-RAY DIFFRACTION (2.93 Å)