4S0T
STRUCTURE OF HUMAN PREGNANE X RECEPTOR LIGAND BINDING DOMAIN BOUND WITH ADNECTIN-1 AND COMPOUND-1
Summary for 4S0T
Entry DOI | 10.2210/pdb4s0t/pdb |
Related | 4S0S 4XHD |
Descriptor | Nuclear receptor subfamily 1 group I member 2, Adnectin-1, N-{(2R)-1-[(4S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl]-3-methyl-1-oxobutan-2-yl}-2-cyclopropylacetamide (3 entities in total) |
Functional Keywords | nuclear receptor, multiple binding modes, xenobiotic, promiscuous, nuclear hormone receptor, transcription |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus : O75469 |
Total number of polymer chains | 4 |
Total formula weight | 99754.76 |
Authors | Khan, J.A.,Camac, D.M. (deposition date: 2015-01-05, release date: 2015-02-04, Last modification date: 2024-02-28) |
Primary citation | Khan, J.A.,Camac, D.M.,Low, S.,Tebben, A.J.,Wensel, D.L.,Wright, M.C.,Su, J.,Jenny, V.,Gupta, R.D.,Ruzanov, M.,Russo, K.A.,Bell, A.,An, Y.,Bryson, J.W.,Gao, M.,Gambhire, P.,Baldwin, E.T.,Gardner, D.,Cavallaro, C.L.,Duncia, J.V.,Hynes, J. Developing Adnectins That Target SRC Co-Activator Binding to PXR: A Structural Approach toward Understanding Promiscuity of PXR. J.Mol.Biol., 427:924-942, 2015 Cited by PubMed: 25579995DOI: 10.1016/j.jmb.2014.12.022 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.14 Å) |
Structure validation
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