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4XHD

STRUCTURE OF HUMAN PREGNANE X RECEPTOR LIGAND BINDING DOMAIN WITH COMPOUND-1

Summary for 4XHD
Entry DOI10.2210/pdb4xhd/pdb
DescriptorNuclear receptor subfamily 1 group I member 2, GLYCEROL, N-{(2R)-1-[(4S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl]-3-methyl-1-oxobutan-2-yl}-2-cyclopropylacetamide, ... (4 entities in total)
Functional Keywordspregnane x receptor, pxr, ligand binding domain, steroid receptor coactivator-1; ccr1, chemokine receptor-1; adnectin nr, nuclear receptor; af, activation function; cyp, cytochrome p450; mdr1, multi-drug resistance gene-1., transcription
Biological sourceHomo sapiens (Human)
Cellular locationNucleus : O75469
Total number of polymer chains1
Total formula weight36736.88
Authors
Khan, J.A.,Camac, D.M. (deposition date: 2015-01-05, release date: 2015-01-28, Last modification date: 2024-02-28)
Primary citationKhan, J.A.,Camac, D.M.,Low, S.,Tebben, A.J.,Wensel, D.L.,Wright, M.C.,Su, J.,Jenny, V.,Gupta, R.D.,Ruzanov, M.,Russo, K.A.,Bell, A.,An, Y.,Bryson, J.W.,Gao, M.,Gambhire, P.,Baldwin, E.T.,Gardner, D.,Cavallaro, C.L.,Duncia, J.V.,Hynes, J.
Developing Adnectins That Target SRC Co-Activator Binding to PXR: A Structural Approach toward Understanding Promiscuity of PXR.
J.Mol.Biol., 427:924-942, 2015
Cited by
PubMed: 25579995
DOI: 10.1016/j.jmb.2014.12.022
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.4 Å)
Structure validation

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