4RNO

Crystal structure of human polymerase eta extending an abasic site-dA pair by inserting dCTP opposite template G

Summary for 4RNO

• Entry DOI: 10.2210/pdb4rno/pdb
• Related: 4RNM 4RNN
• Descriptor: DNA polymerase eta, Nucleic acids Template: CATG(3DR)TGACGCT, Nucleic acids Primar: AGCGTCAA, ... (7 entities in total)
• Functional Keywords: protein, dna, dna damage dna-directed dna polymerase, adenosine triphosphate, y-family polymerase, trans-lesion synthesis (tls), dna binding, abasic site lesion bypass, transferase-dna complex, transferase/dna
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus : Q9Y253
• Total number of polymer chains: 3
• Total formula weight: 55181.96

Authors

Patra, A.,Egli, M. (deposition date: 2014-10-24, release date: 2015-02-18, Last modification date: 2023-09-20)

• Primary citation: Patra, A.,Zhang, Q.,Lei, L.,Su, Y.,Egli, M.,Guengerich, F.P.; Structural and Kinetic Analysis of Nucleoside Triphosphate Incorporation Opposite an Abasic Site by Human Translesion DNA Polymerase eta.; J.Biol.Chem., 290:8028-8038, 2015; PubMed: 25666608; DOI: 10.1074/jbc.M115.637561

Experimental method

X-RAY DIFFRACTION (2.82 Å)