4RIV

A Carbonic Anhydrase IX Mimic in Complex with Saccharin

Summary for 4RIV

Entry DOI	10.2210/pdb4riv/pdb
Related	4RIU
Descriptor	Carbonic anhydrase 2, ZINC ION, 1,2-BENZISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDE, ... (5 entities in total)
Functional Keywords	carbonic anhydrase fold, reversible hydration of co2, active site point mutations, cytosolic, lyase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm : P00918
Total number of polymer chains	1
Total formula weight	29724.76
Authors	Mahon, B.P.,McKenna, R. (deposition date: 2014-10-07, release date: 2015-02-04, Last modification date: 2023-09-20)
Primary citation	Mahon, B.P.,Hendon, A.M.,Driscoll, J.M.,Rankin, G.M.,Poulsen, S.A.,Supuran, C.T.,McKenna, R. Saccharin: A lead compound for structure-based drug design of carbonic anhydrase IX inhibitors. Bioorg.Med.Chem., 23:849-854, 2015 Cited by PubMed: 25614109 DOI: 10.1016/j.bmc.2014.12.030 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.631 Å)

Structure validation