4RIU
A Carbonic Anhydrase IX Mimic in Complex with a Saccharin-Based Inhibitor
Summary for 4RIU
| Entry DOI | 10.2210/pdb4riu/pdb |
| Related | 4RIV |
| Descriptor | Carbonic anhydrase 2, ZINC ION, GLYCEROL, ... (5 entities in total) |
| Functional Keywords | carbonic anhydrase fold, reversible hydration of co2, active site point mutations, cytosolic, lyase-lyase inhibitor complex, lyase/lyase inhibitor |
| Biological source | Homo sapiens (human) |
| Cellular location | Cytoplasm : P00918 |
| Total number of polymer chains | 1 |
| Total formula weight | 29984.98 |
| Authors | Mahon, B.P.,McKenna, R. (deposition date: 2014-10-07, release date: 2015-02-04, Last modification date: 2023-09-20) |
| Primary citation | Mahon, B.P.,Hendon, A.M.,Driscoll, J.M.,Rankin, G.M.,Poulsen, S.A.,Supuran, C.T.,McKenna, R. Saccharin: A lead compound for structure-based drug design of carbonic anhydrase IX inhibitors. Bioorg.Med.Chem., 23:849-854, 2015 Cited by PubMed: 25614109DOI: 10.1016/j.bmc.2014.12.030 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.651 Å) |
Structure validation
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