4RA4

Crystal Structure of Human Protein Kinase C Alpha in Complex with Compound 28 ((R)-6-((3S,4S)-1,3-Dimethyl-piperidin-4-yl)-7-(2-fluoro-phenyl)-4-methyl-2,10-dihydro-9-oxa-1,2,4a-triaza-phenanthren-3-one)

Summary for 4RA4

• Entry DOI: 10.2210/pdb4ra4/pdb
• Related: 4Q9S 4Q9Z
• Descriptor: Protein kinase C, (1R)-9-[(3S,4S)-1,3-dimethylpiperidin-4-yl]-8-(2-fluorophenyl)-1-methyl-3,5-dihydro[1,2,4]triazino[3,4-c][1,4]benzoxazin-2(1H)-one (3 entities in total)
• Functional Keywords: kinase domain, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 41269.96

Authors

Argiriadi, M.A.,George, D.M. (deposition date: 2014-09-09, release date: 2014-10-08, Last modification date: 2024-03-06)

• Primary citation: George, D.M.,Breinlinger, E.C.,Argiriadi, M.A.,Zhang, Y.,Wang, J.,Bansal-Pakala, P.,Duignan, D.B.,Honore, P.,Lang, Q.,Mittelstadt, S.,Rundell, L.,Schwartz, A.,Sun, J.,Edmunds, J.J.; Optimized Protein Kinase C theta (PKC theta ) Inhibitors Reveal Only Modest Anti-inflammatory Efficacy in a Rodent Model of Arthritis.; J.Med.Chem., 58:333-346, 2015; PubMed: 25254961; DOI: 10.1021/jm5013006

Experimental method

X-RAY DIFFRACTION (2.63 Å)