4RA4
Crystal Structure of Human Protein Kinase C Alpha in Complex with Compound 28 ((R)-6-((3S,4S)-1,3-Dimethyl-piperidin-4-yl)-7-(2-fluoro-phenyl)-4-methyl-2,10-dihydro-9-oxa-1,2,4a-triaza-phenanthren-3-one)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Protein kinase C | polymer | 355 | 40847.5 | 1 | UniProt (L7RSM7) Pfam (PF00069) Pfam (PF00433) UniProt (by SIFTS) (P17252) In PDB | Homo sapiens (human) | |
| 2 | A | (1R)-9-[(3S,4S)-1,3-dimethylpiperidin-4-yl]-8-(2-fluorophenyl)-1-methyl-3,5-dihydro[1,2,4]triazino[3,4-c][1,4]benzoxazin-2(1H)-one | non-polymer | 422.5 | 1 | Chemie (3KZ) | |||
| 3 | water | water | 18.0 | 40 | Chemie (HOH) |
Sequence modifications
A: 318 - 672 (UniProt: L7RSM7)
| PDB | External Database | Details |
|---|---|---|
| Ile 568 | Val 568 | SEE REMARK 999 |
| Ser 619 | Cys 619 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 40847.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 422.5 | |
| All* | Total formula weight | 41270.0 |
