4R8Q

Structure and substrate recruitment of the human spindle checkpoint kinase bub1

Replaces:  3E7E

Summary for 4R8Q

• Entry DOI: 10.2210/pdb4r8q/pdb
• Related: 4QPM
• Descriptor: Mitotic checkpoint serine/threonine-protein kinase BUB1, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: spindle assembly checkpoint, mitosis, kinase, activation, ken box, cdc20, atp-binding, cell cycle, cell division, disease mutation, nucleotide-binding, nucleus, phosphoprotein, serine/threonine-protein kinase, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: O43683
• Total number of polymer chains: 1
• Total formula weight: 42323.39

Authors

Tomchick, D.R.,Yu, H. (deposition date: 2014-09-02, release date: 2014-11-12, Last modification date: 2024-02-28)

• Primary citation: Kang, J.,Yang, M.,Li, B.,Qi, W.,Zhang, C.,Shokat, K.M.,Tomchick, D.R.,Machius, M.,Yu, H.; Structure and substrate recruitment of the human spindle checkpoint kinase Bub1.; Mol.Cell, 32:394-405, 2008; PubMed: 18995837; DOI: 10.1016/j.molcel.2008.09.017

Experimental method

X-RAY DIFFRACTION (2.31 Å)