4R67
Human constitutive 20S proteasome in complex with carfilzomib
Summary for 4R67
Entry DOI | 10.2210/pdb4r67/pdb |
Related | 1IRU 1PMA 1RYP 3UNB 3UNE 4R3O |
Related PRD ID | PRD_001243 |
Descriptor | Proteasome subunit alpha type-6, Proteasome subunit beta type-3, Proteasome subunit beta type-2, ... (16 entities in total) |
Functional Keywords | hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Cytoplasm: P60900 P49720 P49721 P28074 P20618 P28070 P25787 P25789 O14818 P28066 P25786 P25788 P28072 Q99436 |
Total number of polymer chains | 56 |
Total formula weight | 1403757.38 |
Authors | Sacchettini, J.C.,Harshbarger, W.H. (deposition date: 2014-08-22, release date: 2015-02-11, Last modification date: 2015-02-18) |
Primary citation | Harshbarger, W.,Miller, C.,Diedrich, C.,Sacchettini, J. Crystal Structure of the Human 20S Proteasome in Complex with Carfilzomib. Structure, 23:418-424, 2015 Cited by PubMed: 25599644DOI: 10.1016/j.str.2014.11.017 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.89 Å) |
Structure validation
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