4R3O

Human Constitutive 20S Proteasome

Summary for 4R3O

• Entry DOI: 10.2210/pdb4r3o/pdb
• Related: 1IRU 1PMA 1RYP 3UNE 4R67
• Descriptor: Proteasome subunit alpha type-6, Proteasome subunit beta type-3, Proteasome subunit beta type-2, ... (15 entities in total)
• Functional Keywords: hydrolase
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm: P60900 P49720 P49721 P28074 P20618 P28070 P25787 P25789 O14818 P28066 P25786 P25788 P28072 Q99436
• Total number of polymer chains: 28
• Total formula weight: 697897.01

Authors

Sacchettini, J.C.,Harshbarger, W.H. (deposition date: 2014-08-16, release date: 2015-01-28, Last modification date: 2024-02-28)

• Primary citation: Harshbarger, W.,Miller, C.,Diedrich, C.,Sacchettini, J.; Crystal Structure of the Human 20S Proteasome in Complex with Carfilzomib.; Structure, 23:418-424, 2015; PubMed: 25599644; DOI: 10.1016/j.str.2014.11.017

Experimental method

X-RAY DIFFRACTION (2.6 Å)