4QTL

Crystal structure of human carbonic anhydrase isozyme II with inhibitor

Summary for 4QTL

Entry DOI	10.2210/pdb4qtl/pdb
Related	4QIY 4QIZ 4QJ0 4QJM 4QJO 4QJP 4QJW 4QJX
Descriptor	Carbonic anhydrase 2, ZINC ION, DIMETHYL SULFOXIDE, ... (6 entities in total)
Functional Keywords	drug design, carbonic anhydrase, benzenesulfonamide, metal-binding, lyase-lyase inhibitor complex, lyase/lyase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm : P00918
Total number of polymer chains	1
Total formula weight	30052.26
Authors	Smirnov, A.,Manakova, E.,Grazulis, S. (deposition date: 2014-07-08, release date: 2015-04-15, Last modification date: 2023-11-08)
Primary citation	Dudutiene, V.,Zubriene, A.,Smirnov, A.,Timm, D.D.,Smirnoviene, J.,Kazokaite, J.,Michailoviene, V.,Zaksauskas, A.,Manakova, E.,Grazulis, S.,Matulis, D. Functionalization of Fluorinated Benzenesulfonamides and Their Inhibitory Properties toward Carbonic Anhydrases Chemmedchem, 10:662-687, 2015 Cited by PubMed: 25758852 DOI: 10.1002/cmdc.201402490 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation