4QIY

Crystal structure of human carbonic anhydrase isozyme II with inhibitor

Summary for 4QIY

Entry DOI	10.2210/pdb4qiy/pdb
Related	4QIZ 4QJ0 4QJM 4QJO 4QJP 4QJW 4QJX 4QTL
Descriptor	Carbonic anhydrase 2, ZINC ION, 2,3,6-trifluoro-5-{[(1R,2S)-2-hydroxy-1,2-diphenylethyl]amino}-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide, ... (6 entities in total)
Functional Keywords	drug design, carbonic anhydrase, benzenesulfonamide, metal-binding, lyase-lyase inhibitor complex, lyase/lyase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm : P00918
Total number of polymer chains	4
Total formula weight	120505.25
Authors	Manakova, E.,Smirnov, A.,Grazulis, S. (deposition date: 2014-06-03, release date: 2015-04-15, Last modification date: 2023-11-08)
Primary citation	Dudutiene, V.,Zubriene, A.,Smirnov, A.,Timm, D.D.,Smirnoviene, J.,Kazokaite, J.,Michailoviene, V.,Zaksauskas, A.,Manakova, E.,Grazulis, S.,Matulis, D. Functionalization of Fluorinated Benzenesulfonamides and Their Inhibitory Properties toward Carbonic Anhydrases Chemmedchem, 10:662-687, 2015 Cited by PubMed: 25758852 DOI: 10.1002/cmdc.201402490 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.3 Å)

Structure validation