4QIK
Crystal structure of the ROQ domain of human Roquin in complex with the TNF23 RNA duplex
Summary for 4QIK
Entry DOI | 10.2210/pdb4qik/pdb |
Related | 4QIL |
Descriptor | Roquin-1, 5'-R(*AP*C*AP*UP*GP*UP*UP*UP*UP*CP*UP*GP*UP*GP*AP*AP*AP*AP*CP*GP*GP*AP*G)-3', CHLORIDE ION, ... (5 entities in total) |
Functional Keywords | rna duplex, winged-helix motif, mrna secondary structure, mrna decay, immune responses, autoimmunity, rna binding protein-rna complex, rna binding protein/rna |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm, P-body (By similarity): Q5TC82 |
Total number of polymer chains | 4 |
Total formula weight | 90452.68 |
Authors | |
Primary citation | Tan, D.,Zhou, M.,Kiledjian, M.,Tong, L. The ROQ domain of Roquin recognizes mRNA constitutive-decay element and double-stranded RNA. Nat.Struct.Mol.Biol., 21:679-685, 2014 Cited by PubMed: 25026078DOI: 10.1038/nsmb.2857 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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