4QIL

Crystal structure of the ROQ domain of human Roquin in complex with the Hmg19 stem-loop RNA

Summary for 4QIL

• Entry DOI: 10.2210/pdb4qil/pdb
• Related: 4QIK
• Descriptor: Roquin-1, 5'-R(*CP*UP*CP*CP*CP*UP*UP*CP*UP*GP*UP*GP*AP*AP*GP*GP*GP*GP*A)-3', CALCIUM ION, ... (4 entities in total)
• Functional Keywords: winged-helix motif, mrna stem-loop, mrna decay, immune responses, autoimmunity, rna binding protein-rna complex, rna binding protein/rna
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm, P-body (By similarity): Q5TC82
• Total number of polymer chains: 4
• Total formula weight: 86650.29

Authors

Tan, D.,Tong, L. (deposition date: 2014-05-31, release date: 2014-07-16, Last modification date: 2023-09-20)

• Primary citation: Tan, D.,Zhou, M.,Kiledjian, M.,Tong, L.; The ROQ domain of Roquin recognizes mRNA constitutive-decay element and double-stranded RNA.; Nat.Struct.Mol.Biol., 21:679-685, 2014; PubMed: 25026078; DOI: 10.1038/nsmb.2857

Experimental method

X-RAY DIFFRACTION (2.9 Å)