4PM9

Crystal structure of CTX-M-14 S70G:S237A:R276A beta-lactamase in complex with cefotaxime at 1.45 Angstroms resolution

Summary for 4PM9

• Entry DOI: 10.2210/pdb4pm9/pdb
• Related: 4PM5 4PM6 4PM7 4PM8 4PMA
• Descriptor: Beta-lactamase CTX-M-14, (6R,7R)-3-(acetyloxymethyl)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyimino-ethanoyl]amino]-8-oxo-5-thia-1-azabicy clo[4.2.0]oct-2-ene-2-carboxylic acid (3 entities in total)
• Functional Keywords: class a beta-lactamase, cefotaxime, hydrolase-antibiotic complex, hydrolase/antibiotic
• Biological source: Klebsiella pneumoniae subsp. pneumoniae
• Total number of polymer chains: 1
• Total formula weight: 28195.74

Authors

Cardenas, A.M.,Adamski, C.J.,Sankaran, B.,Brown, N.G.,Horton, L.B.,Palzkill, T. (deposition date: 2014-05-20, release date: 2014-12-31, Last modification date: 2023-12-27)

• Primary citation: Adamski, C.J.,Cardenas, A.M.,Brown, N.G.,Horton, L.B.,Sankaran, B.,Prasad, B.V.,Gilbert, H.F.,Palzkill, T.; Molecular Basis for the Catalytic Specificity of the CTX-M Extended-Spectrum beta-Lactamases.; Biochemistry, 54:447-457, 2015; PubMed: 25489790; DOI: 10.1021/bi501195g

Experimental method

X-RAY DIFFRACTION (1.454 Å)