4PM9
Crystal structure of CTX-M-14 S70G:S237A:R276A beta-lactamase in complex with cefotaxime at 1.45 Angstroms resolution
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Beta-lactamase CTX-M-14 | polymer | 262 | 27740.3 | 1 | UniProt (G8XD06) Pfam (PF00144) Pfam (PF13354) UniProt (by SIFTS) (A0A0H3H219) In PDB | Klebsiella pneumoniae subsp. pneumoniae | |
| 2 | A | (6R,7R)-3-(acetyloxymethyl)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyimino-ethanoyl]amino]-8-oxo-5-thia-1-azabicy clo[4.2.0]oct-2-ene-2-carboxylic acid | non-polymer | 455.5 | 1 | Chemie (CE3) | |||
| 3 | water | water | 18.0 | 305 | Chemie (HOH) |
Sequence modifications
A: 26 - 290 (UniProt: G8XD06)
| PDB | External Database | Details |
|---|---|---|
| Gly 70 | Ser 73 | engineered mutation |
| Ala 237 | Ser 240 | engineered mutation |
| Ala 276 | Arg 277 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 27740.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 455.5 | |
| All* | Total formula weight | 28195.7 |
